One of the issues that obviously plays an important role in Hazrat Fatemeh’s socialpolitical life is to support guardianship which has a great status in Islam. Hazrat Fatemeh is the first woman who applied strategies and stances to keep the realm of guardianship that always it can be a pattern for followers of guardianship. The present study examines Hazrat Fatemeh’s verbal and behavioral ways to defend the realm of guardianship. The strategies and behaviors applied by Hazrat Fatemeh for defending the realm of guardianship and caliphate of Hazrat Ali are as follows: the announcement of illegitimacy of caliph, the explanation of Hazrat Ali’s personality and the emphasis on his points for immigrants and Ansar by her lectures, the remembrance of the Prophet Mohammad’s words about the characteristics of guardianship especially the expression of Ghadir event, a strong stance against the tolerance and indulgence of elites who were often silent so that they could reach a position, the attempt to keep Muslims informed, the emphasis on taking back Fadak, the rejection of caliph’s reasons on this issue that children do not inherit caliphate from the prophets, the companionship with Imam Ali to prove their righteousness, Bayt al-Ahzan, and finally, his will to be buried at night.