Association of qnrB Gene with Ofloxacin Resistance among Uropathogenic Escherichia coli Isolated from Patients with Urinary Tract Iinfection

Urinary tract infection (UTI) is one of the most common bacterial infections and one of the main causes of patients visiting hospitals. The aim of this study was to investigate the relationship between the presence of qnrB gene and ofloxacin resistance.

In this study, sampling was performed in 1396 and during the spring from Kermanshah hospitals as a census (all available samples). Clinical samples (urine) suspected of generalized urinary tract infection were collected. The qnrB resistance gene was further identified by PCR and finally statistical analysis of the data was performed by SPSS v23.

In this study, 105 Escherichia coli isolates were isolated and identified from clinical urine samples. The resistance of strains to the ofloxacin antibiotic was 33.33%. PCR results showed that 67 strains (63.8%) had the qnrB gene and 38 strains (36.19%) lacked this gene. The results of statistical analysis showed that there was no significant relationship between the presence of qnrB gene and ofloxacin resistance.

The results of this study show that the frequency of qnrB gene among Escherichia coli isolates isolated from urinary tract infections in Kermanshah has a relatively high rate. The results of the present study can be used by physicians to select appropriate measures for the treatment and prevention of improper administration of antibiotics.