The Association of Glomerular Filtration Rate with Coronary Artery Disease in Type 2 Diabetic Patients

Chronic kidney disease (CKD) and diabetes mellitus can influence coronary artery disease (CAD) independently. The aim of this study was to evaluate the association of glomerular filtration rate (GFR) and CAD in type 2 diabetic patients (T2DM).

This cross sectional study evaluated 3624 T2DM patients with clinical presentation of CAD whose documents were registered in angiography center of Shahid Mohammadi Hospital in Bandar Abbas, Iran during 18 months. GFR was measured by MDRD method and divided into 5 subgroups: GFR< 15, 15≤ GFR< 30, 30≤ GFR< 60, 60≤ GFR< 90 and GFR≥ 90. Then the association of 5 subgroups of GFR with coronary angioplasty in T2DM patients was evaluated. T-test was used to compare the mean of quantitative variables, and chi-squared test for qualitative variables. Using SPSS- 22 the collected data were analyzed and P-value< 0.05 was significant.

Among 3624 T2DM patients, 36% had GFR< 60 (ml/min/1.73m2).The highest frequency percentage of coronary angioplasty (53%) was observed in the GFR stage 3 (30-60) ml/min/1.73m2. A significant inverse association was observed between the GFR of T2DM patients and the frequency of CAD. (P-value< 0.001). There was also a significant association between GFR< 60 and history of hypertension and dyslipidemia. (P-value< 0.001).

A reduced GFR in patients with diabetes has associations with CAD.