The Effect of an Eight-Week Resistance Training on ActRIIβ in the Myocardial Left Ventricular and Plasma Levels of GDF11, GDF8 in Old Male Rats

Exercise trainings have beneficial effects on myocardium by changing the concentration of growth factors and their receptors and reduces the risk of heart failure. The aim of this study was to determine the effect of an Eight-week resistance training on ActRIIβin the myocardial left ventricular and plasma levels of GDF11, GDF8 in old male rats.

After the familiarization period, fourteen old male rats with age range 24 to 27 months were randomly divided into control (n= Seven) and training (n= Seven) groups. Resistance training was included eight weeks and five sessions per week climbing from a 1-meter ladder. GDF11 and GDF8 were measured by ELISA method and ActRIIβin the myocardial left ventricular was measurement by IHC method. Independent t-test was applied for statistical analysis of the data (p≤0.05).

Comparisons between groups showed a significant difference between the training and control groups in GDF11 (p≤0.001), GDF8/GDF11 (p≤0.001), GDF8 (p≤0.027) and heart weight (p≤0.031). Between groups comparisons not showed a significant difference between the training and control groups in myocardium ActRIIβ (p>0.05).

It seems that resistance training is effective in Seniors cardiac physiological hypertrophy with beneficial effects on growth factors. Therefore, these trainings can be used to reduce the incidence of heart failure; however, more studies are needed in this regard.