AN EVALUATION OF EFFECTS OF THREE DIFFERENT METHODS OF OVULATION INDUCTION: CLOMIPHEN, CLOMIPHEN+ PREMARIN, CLOMIPHEN+ HMG ON ENDOMETRIAL THICKNESS AND PATTERN
Author(s):
Abstract:
The aim of this prospective clinical study was to determine the effect of different methods of ovulation induction on the pattern and thickness of the endometrium. For this purpose, 150 patients were recruited and divided randomly into in three groups: Group I: (Clomiphen-only group), which consisted of 60 patients, who received oral clomiphen daily for five days starting on day 3 of menstruation. Group II: (clomiphen + premarin group), which consisted of 30 patients who received oral clomiphen as above in addition to 1.25 g premarin for 10 days. Group III: (clomiphen + HMG), which consisted of 60 patient who received clomiphen as above in addition to HMG (2 to 4 injections). Measurement of follicular growth and endometrial thickness and pattern was determined by vaginal sonography. The results showed that the average number of follicles was 1-3 and follicular size was 19-23 mm. The average thickness of the endometrium was 7.99 mm in group I, 8.27 mm in group II and 7.94 mm in group III. The triple line pattern was 63.3% in group I, 72.4% in group II and 66.7% in group III. Endometrial thickness of  6mm was 35% in group I, 24.1% in group II and 28.3% in group III. These results suggest that the best endometrial pattern was observed in clomiphen-premarin group, and the worst pattern with least endometrial thickness was observed in clomiphen-only treated group. Endometrial thickness of equal to or less than 6mm, bad prognostic group for pregnancy, were more frequent in group I.. More than 60% of all patients had endematrial thickness of >6 mm and triple line pattern and statistical analysis did not show any significant differences between these groups. The overall conclusion suggests that clomiphen plus premarin to be more effective for promotion of induction of ovulation
Language:
Persian
Published:
Jundishapur Scientific Medical Journal, Volume:3 Issue: 43, 2005
Page:
71
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