Investigating the response of lipid profile, insulin resistance and mitochondrial biogenesis of obese rats to various training
Message:
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background and Objective

The aim of this study was to investigate the response of lipid profile, insulin resistance, and mitochondrial biogenesis index of obese rats to various exercise training.

Material and Methods

24 rats were randomly divided into four groups of 6: 1) obese-interval training (HIIT); 2) obese-continuous training (CT); 3) obese control (OB) and 4) control (Cont). During the study period, (from 16 to 24 weeks) rats in groups 1, 2, and 3 were given high-fat foods (from 16 to 24 weeks). After being familiarized, rats in groups 1 and 2 performed HIIT and continuous training three times a week for eight weeks, respectively. Data were analyzed with one-way ANOVA and Bonferroni posthoc test (p≤0.05).

Results

A study of Western blotting showed that the amount of muscle PGC1α in HIIT and CT groups was significantly higher than OB and Cont groups. Also, despite the more reduction in visceral fat and other factors in the CT group, the HIIT groupchr(chr('39')39chr('39'))s PGC1α content was higher than the CT group, which was not significant. Serum levels of glucose, insulin, and insulin resistance in HIIT and CT groups (At 24 weeks) were significantly lower than the OB group (p≤0.05); However, these glycemic indices weren’t significantly different from the control group (P≥0.05). There was a significant difference in TG, TC, LDL, and HDL values between the exercise groups with the OB group. In addition, the increase in visceral fat was 27% in the OB group, while a decrease of 30% and 43% was observed in the HIIT and CT groups, respectively (P<0.05).

Conclusion

It seems that the use of HIIT can be as effective as continuous training on lipid profile, insulin resistance, and mitochondrial function of muscle tissue in obese people.

Language:
English
Published:
Jorjani Biomedicine Journal, Volume:9 Issue: 2, Summer 2021
Pages:
55 to 67
magiran.com/p2295334  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 990,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
دسترسی سراسری کاربران دانشگاه پیام نور!
اعضای هیئت علمی و دانشجویان دانشگاه پیام نور در سراسر کشور، در صورت ثبت نام با ایمیل دانشگاهی، تا پایان فروردین ماه 1403 به مقالات سایت دسترسی خواهند داشت!
In order to view content subscription is required

Personal subscription
Subscribe magiran.com for 50 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!