Evaluation of anatomical location of prostate cancer and frequency of extraprostatic extension (EPE) and seminal vesicle invasion (SVI) in systematic prostate biopsies

Prostate cancer is the most common visceral cancer recognized in men. Considering the incidence of prostatic cancer in our country, evaluation of anatomical location of prostatic cancer and frequency of extraprostatic extension (EPE) and seminal vesicle invasion (SVI) as important prognostic factors, could be of great importance.

Patients suspected of prostatic cancer were subjected to transrectal systemic needle biopsy. 12 to 14 samples from different prostate anatomical regions were prepared.In pathology lab Based on morphology or if necessary with the help of immunohistochemical methods, 68 Patients with prostate cancer as well as extra-prostatic involvement in the sample ,received the criteria for entering the study. Pathologist  determined the anatomical location of prostate conflict. Data and statistical analysis were used to find out the relation between anatomical location of prostate cancer and EPE and SVI.

Patient’s mean age was 73.82 year. 29 patients (42.6%) had seminal vesicle invasion. In 41 patients (60.3%) all 12 biopsies were involved. In 90% cases involvement of the base region were seen. Also, the average rate of involvement of various margins was 10.97 out of 12 biopsies.In 97.05%    of patients half and more than half of biopsies were involved. The mean serum PSA level before surgery in patients was 53.64 ng/dL.

There was no significant relationship between anatomic region of prostate cancer and extraprostatic extension(EPE) or seminal vesicle invasion(SVI).Also as our study showed more biopsies involved with cancer ,more EPE and SVI were seen. Patients with EPE and SVI had higher mean age.