The Effect of Carotenoid Rhodoturola glutenis on Liver Function in Male Mice

Carotenoids have received much attention due to their conversion to vitamin A in the body, reducing the risk of destructive diseases, antioxidant activity, improving immune function and their application as edible colors.

In this quasi-experimental study conducted in 2018, 24 male albino mice were included in the study and randomly divided into 3 groups of 8. The two groups received 32 mg/kg and 16 mg/kg carotenoids peritoneally. The control group received 0.5 ml of distilled water intraperitoneally, then blood sampling was performed and liver health in mice was assessed by measuring the GGT, ALP, SGOT and SGPT factors. The obtained results were analyzed using analysis of variance and Anova statistical tests in SPSS21 software.

In this study, the amount of carotenoids isolated from the yeast of Rhodoturola glutenis was equal to 0.1 mg/L and the results of the related food industry with a purity of: 12.21 mg%, moisture content of 18 mg/L, ash. Total: 9.6 mg percent, volatiles: 9.8 mg percent, acid number 7.3 mg percent and pH: 5.5 was stated. The mean activity of SGOT, SGPT, ALP in the 32 and 16mg/kg injections was not significantly different with the control group. But the mean of GGT activity in the 32mg/kg treated group was significantly less than the 16mg/kg injection group.

According to the results of this study, Rhodotorula glutinis carotenoids was not significantly different in liver enzyme activity in treatment and control group. But, the GGT activity is an important marker of oxidative stress. The mean of GGT activity in the 32mg/kg injection group was significantly less than other group. On the other hand, gammaglutamyl transferase is one of the markers of oxidative stress. Due to the inverse activity of GGT and its antioxidant properties, the reason for the decrease in the activity of this enzyme in the injected group at a dose of 32 mg / kg carotenoid is probably the dose-dependent antioxidant effects of most carotenoids. So, it is recommended to use it as a supplement in the food industry.