The role mediating social isolation in relationships between brain-behavioral systems and HEXACO personality characteristics with distress tolerance in people with substance dependence

One of the biggest problems of human societies is the substance dependence problem, which endangers the health of the community, family and the individual, causing loss of personal, occupational, family and social functions. Therefore, purpose of this study was to role mediating social isolation in relationships between brain-behavioral systems and HEXACO personality characteristics with distress tolerance in people with substance dependence. The descriptive- correlation method was used. The statistical population consists of all men with substance dependence referring to addiction treatment centers in Tehran city in year 2020. In this study, according to convenience sampling method, 400 people with substance dependence by formula Kline (2015) were selected as samples and they were asked to distress tolerance scale of Simons and Gaher, brain-behavioral systems scale of Carver and White, HEXACO Personality Inventory of Ashton and Lee and social isolation scale of Russell. After exclusion of 63 outlier data was finally, 337 people were analyzed with using SPSS and AMOS-24 software was investigated. The results showed that most direct paths were significant. The indirect relationship HEXACO personality characteristics (honesty- humility, extraversion and agreeableness) with distress tolerance through moderating role social isolation was significant in people with substance dependence, also indirect relationship brain-behavioral systems with distress tolerance through moderating role social isolation was not significant. The structural model of research was fit and satisfactory with research data and is an important step in identifying the factors that are effective in social isolation in people with substance dependence.