The effect of chlorpyrifos toxicity on hematological indices of Nile tilapia, Oreochromis niloticus fed with different levels of prebiotic Pleurotus Ostreatus

This study aimed to investigate the effect of different levels of prebiotic Pleurotus ostreatus on hematological indices of Nile tilapia, Oreochromis niloticus exposed to chlorpyrifos toxin.A total of120 fish were distributed for 42 days in 4 treatments (each with 3 replicates), including control (1), no prebiotic fungi, (2) food containing 0.05, (3) food containing 0.1 and (4) food contained 0.2% prebiotic. Then, 0.5 ppm of Chlorpyrifos was added to each group for 16 days and their blood parameters were examined. Based on the results, prebiotic alone had no significant effect on erythrocyte count, mean cell volume (MCV), hematocrit, hemoglobin, white blood cell (p < /em><0.05) but exposure to Chlorpyrifos and prebiotic in combination increased the mentioned factors compared to the control and prebiotic treatments alone. However, the levels of white blood cells and erythrocytes, hemoglobin, hematocrit, and MCHC were higher than the other treatments in the combination of 0.2 and 0.1% prebiotic and Chlorpyrifos. It is concluded that the 0.1 and 0.2% prebiotic level could have the best effect on the blood indices of Nile tilapia.