The effect of high-intensity resistance training on Irisin and Fibroblast growth factor 21 levels in overweight men

Obesity is a metabolic disorder that can be controlled and prevented by increasing energy expenditure and stimulating factors related to the browning of white adipose tissue. The aim of this study was to investigate the effect of high-intensity resistance training on Irisin and Fibroblast growth factor 21 (FGF21) levels in overweight men.

In this semi-experimental study, 20 overweight men (mean 36.56± 3.33 years and body mass index 29.41± 3.02 kg/m2) were randomly selected. They were assigned in two groups of high-intensity resistance training and control. The program of the Resistance Group was conducted in a circular shape with an intensity of 85-80% of a maximum repetition, three sessions per week for eight weeks. 24 hours before and 48 hours after the training period, serum Irisin levels and FGF21 subjects were measured in the fasting state. Data analysis was performed by correlated t-test and ANCOVA at the significance level of P<0.01.

Irisin and FGF21 Serum levels in the high-intensity resistance training group showed a significant increase compared to the control group (P<0.01). Bodyweight, BMI, and body fat percentage in the high-intensity resistance training group showed a significant decrease compared to the control group, while a significant increase was observed in the control group (P<0.01).

It seems that high-intensity resistance training can be emphasized as an effective step in convert white adipose tissue to brown and improving the body composition of overweight and obese people.