Central nervous system disorders, including Parkinson's Disease (PD), are growing pathogenic incurable diseases. In PD, with the loss of neurons especially in the areas which produce and secrete dopamine, the patient is facing with irreversible motorized and perceived complications. Neuronal damage and death are usually accompanied by increasing the expression of alpha-synuclein (αSN) protein. Rotenone, a known neurotoxin, is also contributed to PD by inducing oxidative stress. In this study, we investigated the effect of the extracts of three Iranian olive cultivars on the PD cell model which overexpresses αSN. These cells react strongly to rotenone through which, above and beyond neurotoxicity, the length of the neurites is also reduced in the treatment with rotenone. Some extracts played a protective role in rotenone-treated cells and decreased intracellular reactive oxygen species (ROS) significantly. The radical scavenging activity of the extracts suggested that these reagents can play a protective role on neuronal cells through this mechanism; however, due to the different behavior of the extracts in the extracellular environment, it seems that more complex mechanisms are involved in their neuronal protective effect. This study showed that original Iranian olives belong to Roghani and Zard cultivars could protect the neurons against damage adopted from toxins and αSN and finally could be used in the diet to prevent PD.
- دسترسی به متن مقالات این پایگاه در قالب ارایه خدمات کتابخانه دیجیتال و با دریافت حق عضویت صورت میگیرد و مگیران بهایی برای هر مقاله تعیین نکرده و وجهی بابت آن دریافت نمیکند.
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.