Immunoinformatics study of encoded lysines in bacteriophages effective on Pseudomonas genus bacteria

Pseudomonas is considered as one of the most opportunistic and pathogenic microbes. Due to its high resistance to antibiotics, this bacterium has also encouraged the researchers to introduced alternative therapies, including phage therapy.

Recognition of the family of phages affecting the family of Pseudomonas and evaluation of the immunogenicity of antimicrobial lysine are considered here.

Here, the physio-chemical features of the family of phages affecting the bacterium Pseudomonas was investigated using bioinformatic and immunoinformatic databases. The secondary and tertiary structures of the lysines and the capacity of antigenicity in the host cells were determined.

The results showed that the three bacteriophage families Siphoviridae, Myoviridae, podoviridae with more than 90% abundance had the highest frequency among the bacteriophage families affecting Pseudomonas genus. Analyses of the lysine sequences of each of these three families showed immunity in only half of the total amino acids with a numerial value of half of the threshold of the software for B cells. 1% of amino acids had a strong affinity for MHC molecules those subjected to T cells. Total resulting:Due to the low induction of the immune response by phage lysine protein, they can be a candidate as alternative therapies for antibiotic resistance.