Comparison of the therapeutic effects of Minoxidil 5% solution alone with Flutamide 2% and Minoxidil 5% mixed solution in patients with androgenetic alopecia referring to dermatology clinic of Isfahan university of medical sciences

A special type of alopecia called androgenetic alopecia is one of the most common skin and hair diseases, and topical minoxidil solution is one of the best treatments. Studies have shown that the use of topical 5% minoxidil solution in patients with androgenetic alopecia reduces hair loss, increases patients' satisfaction with recovery and increases hair growth. Also, the therapeutic effects of flutamide in women with hair loss have been shown that flutamide is a very suitable treatment regimen for the treatment of these patients and its low doses are very suitable and have few side effects. Accordingly, the aim of this study was to compare the therapeutic effects of 5% minoxidil solution with the combined solution of minoxidil 5% and flutamide 2% in patients with androgenetic alopecia referring to Isfahan Skin Clinic.

This study was a randomized double-blind clinical trial that was conducted as a preliminary study from the summer of 1397 to the summer of 1398 in Al-Zahra Hospital. After identifying patients with mild to moderate androgenetic alopecia as a simple coincidence available to 40 people, they were randomly divided into two groups of cases and 20 subjects. Patients in the control group received 5% minoxidil solution, 1 cc each 20 drops 2 times a day, and patients in the combined group received 2% flutamide and 5% minoxidil in the same way for 9 months. The required data were collected based on the checklist. After collecting the data in SPSS software, version 22 was examined at a significance level of 0.05.

There was no significant difference between gender, age, hair thickness in the two groups of case and control (P>0.05), but there was a significant difference between hair thickness in the two groups of case and control after intervention (P<0.05). There was no significant difference between hair thickness in the case and control groups before the intervention (P>0.05), but there was a significant difference after the intervention (P<0.05). There was a significant difference between hair thickness in the case group before and after the intervention (P<0.05), but there was no significant difference in the control group before and after the intervention (P>0.05). There was a significant difference between hair size in the case and control group before and after the intervention (P<0.05). However, the difference between the mean of the control group before and after the intervention does not show much difference. There was a significant difference between patient satisfaction and physician satisfaction in both case and control groups (P<0.05). There was no significant difference between the time of admission in the two groups of case and control (P>0.05).

According to the results of this study and since conducting this study was an introduction to better understanding the therapeutic effects of minoxidil and flutamide in the treatment of androgenetic alopecia and comparing its therapeutic effects in men and women with androgenetic alopecia, so the necessary measures can be taken. He used a combination of these two drug solutions.