Relationship between Vitamin D3 Levels and Severity of Atopic Dermatitis in Infants and Children

Atopic dermatitis (AD) is a common and drug-resistant inflammatory skin disease and its prevalence is 9-20% throughout the world. Vitamin D has been recently suggested as a potential option for AD treatment. The goal of this study was to assess Vitamin D3 levels in infants and children with AD and investigating the relationship between Vit D3 levels and AD severity.

A cross-sectional analytical study was carried out in children diagnosed with AD attending the Allergy and Immunology Clinics in Urmia Shahid Motahari Hospital, West Azarbaijan province, Iran. One-way ANOVA was applied to understand the relationship between disease severity and Vit D3 levels. All data analyses were performed in SPSS V16.

In this research, 46 people, including 29 males (63%) and 17 females (37%) were studied. Mean age of patients was 36.36±4.85 months, mean SCORAD (SCORing Atopic Dermatitis) was 45.94±2.84, and mean vitamin D3 levels were 30.70±2.35 ng/mL. Findings showed significant relationship between decrease in SCORAD and increase in vitamin D3 levels (P=0.046).

The current study, consistent with other studies, showed significant relationship between vitamin D3 levels and AD severity.