Protective effect of a HIIT training course on some apoptotic markers following acute myocardial infarction in male rats

Apoptosis plays an important role in the development of cardiovascular complications, especially acute myocardial infarction. Evidence suggests that exercise can alter the pathways of myocardial apoptosis. Therefore, the aim of this study was to determine the effect of two weeks of intense intermittent exercise on Bax, Bcl-2 and Caspas-3 in the heart tissue of male rats.

20 male Wistar rats aged 8 weeks (mean weight 224.41 5 5.1 g) were randomly divided into 4 groups: control, training, stroke and stroke-training. The training groups performed two weeks of intense intermittent training in four sections. The first section received two sessions three days a week, each session consisting of four intense two-minute intervals at a speed of 35 to 40 meters per minute, with an active 2-minute rest interval between the two rotations. The exercises of the second part included two days a week, two sessions each day containing 4 intense 2-minute intervals and 3 2-minute active rest intervals. The third section, on three days a week, included 5 intense cycles and 4 active rest cycles. The fourth part consisted of two days a week with the same intensity as the third part, but with an increase in the frequency of activity and active rest in each session. Finally, Bax, Bcl-2 and Caspas-3 proteins were measured using ELISA kit in blood samples taken from heart tissue and the data obtained using the analysis of variance were measured. Paths were analyzed at a significance level of 0.05.

There was a significant decrease in Bax and Caspas-3 indices between exercise-stroke and stroke groups (P = 0.000), but Bcl-2 index in exercise-stroke group increased significantly compared to stroke group. (P = 0.000) was associated.

Based on the results of the present study, performing 2 weeks of intense intermittent exercise reduces apoptosis and myocardial infarction and can protect the heart from possible injuries.