Stereological study on the protective effect of royal jelly on kidney tissue following silver nanoparticles – induced toxicity in the NMRI mouse

Increased use of silver nanoparticles in consumer products may have beneficial or detrimental effects on the structure of the human body and living organisms Since one of the target organs of silver nanoparticles in living organisms is the kidney, the kidney plays a key role in clearing the body of waste products and regulating homeostasis. The aim of this study was to investigate the effect of royal jelly on rat kidney tissue following the toxicity of silver nanoparticles.

24 adult NMRI mice were divided into 4 groups: control, silver nanoparticles (500 mg /Kg/day, gavage), royal jelly (300 mg /Kg/day, gavage) and silver nanoparticles with royal gel and treated for 35 days. Kidney tissue was evaluated by stereologic methods. Biochemical parameters of malondialdehyde, urea, creatinine and total antioxidant activity were analyzed by FRAP method. Data were analyzed by one-way ANOVA and Tukey tests and the difference was considered significant (p