The effect of Eryngium campestre hydroalcoholic extract on glucose and lipid indices of the blood in streptozotocin-induced diabetic male rats

Diabetes or impairment in the secretion or function of insulin, in addition to increasing blood sugar, causes changes in blood lipid parameters. This study was designed and performed to investigate the effect of E. campestre extract on blood sugar levels and blood lipid indices in diabetic male rats. In this experimental study of adult male Wistar rats (200-250 gr) in five groups of 8 (n=8): 1) saline (control) 2) untreated diabetes (control) 3, 4 and 5) Diabetic patients treated with E. campestre extract (50, 100, 200 mg / kg) were used. Mice became intraperitoneally diabetic with STZ (60 mg/kg). On the fifth day after receiving STZ, animals with blood glucose above 200 mg/dL were considered diabetic. The control and witness groups received saline only and the treated diabetic groups received E. campestre extract by gavage for two weeks. Finally, after measuring blood glucose and deep anesthesia with ketamine / xylsin, blood samples were taken from the animal's heart and its serum was isolated to evaluate lipid parameter. Administration of different doses of E. campestre extract significantly reduced blood sugar (p<0.001), triglyceride (p<0.001) and VLDL (p<0.001) in treated diabetic rats, but LDL (p<0.001) Increased significantly. E. campestre extract significantly increased total cholesterol (p<0.05) at 100 mg/kg dose and HDL at 100 mg/kg (p<0.05) and 200 (p<0.001) doses. E. campestre extract, while lowering blood sugar, helped improve some impairment caused by diabetes in the lipid parameters.