Effects of Hypericum perforatum and Aloe vera extracts in rat open wounds inoculated with Staphylococcus aureus: clinical and histopathol-ogy aspects

Staphylococcus aureus is an important cause of wound infection and found on the skin of normal human and animal population. Hypericum perforatum and Aloe vera have antioxidant, anti-inflammatery and antibacterial effects, so they can affect on wounds positively together. For this purpose, 40 rats were selected and randomly divided into 4 groups: negative and positive control groups and two groups that treated with Hypericum perforatum and Aloe vera ointments that containing 1 and 4 percent extracts. The wounds were pictured on 0, 3,7 and 14 days after wound creation and the wound healing rates was calculated clinically. Histopathologic stadies were performed on samples collecteal from the wounds in 3,7 and 14 days after wound creation. Finally, the data were analyzed by Anova, Kruskal wallis test. The percentage of wound healing in 3th day in two groups treated with ointment containing extract was higher than other groups. on the 14th day the clinically epithelial tissue of the two groups treated with plant extracts was better than the other two groups. Appendices of the skin like hair follicles are formed in two groups contains extracts, but in the extract of %4 was observed more better than the other three groups becase the sebaceous glands were just observed in this group and quality of epithelial tissue was more better. The results show that ointment containing %4 Aloe vera and Hypericum perforatum extracts have better healing effects and skin beauty results than %1 ointment on wounds that inoculated with Staphylococcus aureus.