The Role of Oxidant-Antioxidant Status in Suicide Behavior in Kurdish Ethnicity

Author(s):

Mahin Oshnokhah , Maryam Bagheri , Hori Ghaneialvar , Karimeh Haghani , Ali Khorshidi , Ali Shahbazi , Sajjad Salari*

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Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Introduction

Oxidative stress plays a critical role in the pathogenesis of neurodegenerative and neuropsychiatric disorders. However, its role in suicidal behavior has not been clarified yet. Consequently, we aimed to evaluate the oxidant-antioxidant status in the serum of suicide attempters in Ilam city. 

Methods

Fifty suicide attempters and 40 control subjects (volunteers) aged 18-35 years were studied in the current experiment. To consider the oxidant-antioxidant status, serum levels of Malondialdehyde (MDA), Nitric Oxide (NO), Superoxide Dismutase (SOD), and the Total Antioxidant Capacity (TAC) were measured. 

Results

Serum levels of SOD and TAC were significantly lower in the suicide attempters group compared to the controls. Furthermore, serum NO level was significantly higher in the suicide attempters compared to the control groups. Interestingly, the serum level of MDA was significantly lower in the suicide attempters compared to the control groups.

Conclusion

The oxidative stress without MDA elevation, detected in suicide attempters, can be considered a biochemical hallmark in suicide behavior.

Keywords:

Suicide behavior , Oxidative stress , TAC , MDA , SOD

Language:
English
Published:
Basic and Clinical Neuroscience, Volume:12 Issue: 5, Sep-Oct 2021
Pages:
667 to 674
https://www.magiran.com/p2374229  
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