Effect of Coenzyme Q10 on oxidative/antioxidative biomarkers level in the testis of streptozotocin-induced diabetic rats

Oxidative stress, through the production of reactive oxygen species (ROS), has been proposed as the root cause underlying the development of diabetes and its related complications such as testicular tissue damage. Antioxidants supplementation have been reported to improve testicular function and oxidative stress-induced in diabetes.The study aimed to determine the Coenzyme Q10 (CoQ10) effects on the oxidative status in the testicular tissue of streptozotocin-induced diabetic rats.

In the experimental study, 30 male Wistar rats were studied. The rats were randomly divided into four 5-rat groups including: saline, sesame oil (as a vehicle), healthy group treated with CoQ10 (10 mg/kg/day), diabetic (induced with streptozotocin: 55 mg/kg), and CoQ10-treated diabetic (10 mg/kg/d). Then, levels of Malondialdehyde (MDA), Total Oxidant Status (TOS), and Total Antioxidant Capacity (TAC) and Oxidative stress index) OSI were measured in the homogenized of testicular tissue.

Analysis of data showed a significant decrease in the level of testis MDA (P=0.001), TAC (P=0.029) and OSI (P=0.033) in the CoQ10-treated diabetic group compared to the diabetic rats. No significant change was observed in the TOS (P=0.529) level in diabetic rats' testis treated with CoQ10 compared to diabetic rats.

Collectively, our results demonstrated the possible effects of CoQ10 in attenuating diabetes-induced oxidative damage, in testicular tissue.