DETERMINING THE RELATIONSHIP BETWEEN AMNIOTIC FLUID GLUCOSE LEVEL AND MATERNAL BMI, FETAL BIRTH WEIGHT, AND MATERNAL BLOOD SUGAR IN MOTHERS UNDERGOING SECOND-TRIMESTER GENETIC AMNIOCENTESIS: A PROSPECTIVE COHORT STUDY

Early diagnosis of gestational diabetes and subsequent treatment plays a vital role in preventing the consequences of pregnancy. According to the results of previous studies about the increase in amniotic fluid glucose levels following gestational diabetes, this study aimed to determine the relationship between amniotic fluid glucose level and maternal BMI, fetal birth weight, and maternal blood glucose in mothers undergoing second-trimester genetic amniocentesis.

This study is a prospective cohort design performed on 115 pregnant women who underwent amniocentesis in the second-trimester of pregnancy at Kowsar Obstetrics and Gynecology Center. Data were collected using a checklist that assesses the initial demographic characteristics of individuals, including maternal age, severity, parity, gestational age, maternal weight and height, BMI, macrosomic birth history, history of preterm delivery, and abortion. The validity and reliability of the checklist were previously confirmed by the professors of the obstetrics and gynecology and Cronbach's alpha coefficient.

 The results of the present study showed that amniotic fluid glucose has a positive and significant correlation with age, fasting blood sugar, amniotic fluid volume, and birth weight of the fetus. Also, pregnant mothers with gestational diabetes had higher fasting blood sugar, fetal birth weight, amniotic fluid volume, and amniotic fluid glucose and had a significant difference with non-patients.

 With all the limitations of the present study, the results showed that amniotic fluid glucose could be used as a factor in the follow-up and consideration of pregnant mothers for gestational diabetes and fetal birth weight.