PUTATIVE ROLE OF STEM CELLS IN THE ALLEVIATION OF ISCHEMIC HEART DISEASE; A REVIEW ARTICLE

Cardiovascular disease is touted as one of the leading casualties in the world and accounts for a third of all deaths. In recent years, stem cells have been introduced as a novel and reliable therapeutic approach for the alleviation of cardiovascular disease. In cell-based therapies, induction of angiogenesis into the ischemic areas is at the center of attention of clinical and basic science specialists. It has been shown that pluripotent stem cells as well as stem cells and progenitor cells drived from tissues like bone marrow are eligible to stimulate angiogenesis to return functionality of ischemic tissues.

The present study is a descriptive review study and several articles indexed in PubMed, ISI and Scopus databases on the effective role of stem cells from various sources in stimulating angiogenesis in damaged heart tissue based on repair mechanisms. Has been reviewed. In addition, an attempt has been made to effectively explain the ability of stem cells to increase or improve angiogenic status in ischemic conditions in terms of basic molecular mechanisms.

The results has been shown that stem cells could increase blood flow to the ischemic region of the heart through secretory (paracrine) methods as well as differentiation into the endothelial cell line and accelerate the healing process of damaged areas.

The use of cell therapy-based methods to increase blood flow to the affected areas of the heart is an effective strategy to improve cardiac tissue function.