Ischemic stroke is the second leading cause of death and the third leading cause of disability worldwide. The present study aimed to explore the antidepressant and antioxidant activities of the cyanobacterium Nostoc commune (N. commune) in a rat brain ischemia/reperfusion model.
In this experimental study, thirty-five male Wistar rats were randomly divided into five groups (control, N. commune, ischemia, N. commune 35 + ischemia, and N. commune 70 + ischemia). Rats were pre-treated with N. commune (35 or 70 mg/kg bodyweight, dissolved in saline, once orally) for 14 days, while the rats in control and ischemia groups were given an equivalent volume of saline. The antidepressive‐like effects of N. commune were determined by tail suspension and forced swimming tests 48 hours after ischemia induction. Catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities were assayed in the brain cortex.
The present study exhibited Nostoc commune treatment (70 mg/kg) significantly attenuated the immobility times induced by ischemia damage in FST and TST and reversed the climbing time. Compared to the ischemia group, N. commune treatment considerably increased cerebral CAT, SOD, and GPx activities.
These findings demonstrated that N. commune extract could protect ischemia -induced brain injury rats by inhibiting cerebral oxidative stress, suggesting that it may have potential as a therapy for cerebral ischemia/reperfusion injury.
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