Fear of labor pain causes to lower rate of NVD and increased c/s. Entonox inhalation is an effective method for pain relief of NVD. Our goal is to investigate side effects of N2O on mother & fetus.
This Randomized clinical study has been done on 178 primiparous full term pregnant women, candidate for NVD. Entonox and oxygen were administrated for case and control group, respectively. Maternal age, gestational age, evidences of placental abruption before and after delivery, type of delivery, meconium passage, APGAR Score, symptoms such as nausea, vomiting, vertigo, dryness of mouth, drop in Hb level are investigated.
The mean pain score at the 1st to 5th hours in the Entonox group was significantly lower than the oxygen group (Pvalue <0.001). But at six hours after the intervention, the pain score in the Entonox group with a mean of 8.8± 0.9 was not significantly different from the oxygen group with a mean of 9.0 ± 0.9 (P value> 0.05). The incidence of hemoglobin loss in the oxygen group was significantly higher than the Entonox group (P value <0.001); but the two groups did not differ significantly in terms of decolonization during delivery, accelerated delivery, fetal meconium, Apgar scores of 1 and 5 minutes and type of delivery (P value> 0.05).
Use of Entonox for labor pain relief has small and not significant side effects on mother & fetus. Entonox caused lower levels of blood loss probably because of its useful effects on course of labor.
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