Antioxidant Potential and Antimicrobial Activity of Laurus nobilis Ethanolic Extract on Shigella dysenteriae, Escherichia coli, Listeria monocytogenes and Staphylococcus aureus “in vitro”
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Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background and objectives

Due to potential toxicity and other concerns, the current generation believes in natural products instead of synthetic ones. Therefore, one of the emerging technologies is the extraction of extracts from various plant organs and there in the pharmaceutical and food industries. In this study, ethanolic extract of Laurus nobilis was obtained and its antioxidant and antimicrobial activity was investigated.

Materials and methods

In this study, disk diffusion agar, well diffusion agar, minimum inhibitory concentration, and minimum bactericidal concentration were used to determine the antibacterial activity of L. nobilis ethanolic extract against Shigella dysenteriae, Escherichia coli, Listeria monocytogenes and Staphylococcus aureus. In addition, total phenol content, total flavonoids, and antioxidant activity (based on DPPH and ABTS free radical scavenging and β-carotene/linoleic acid bleaching tests) of the extract were investigated.

Results

Concentration of 60 mg/ml of the extract caused the highest antimicrobial effect. The mean diameter of the growth inhibition zone was larger for Gram-positive bacteria than for Gramnegative bacteria, and lower concentrations of the extract were required to prevent the growth of or kill Staphylococcus aureus. The contents of total phenols and flavonoids in L. nobilis extract were 29.32 mg of gallic acid and 19.16 mg of quercetin per gram of extract. The extract quenched DPPH and ABTS free radicals by 70.60 and 66.50% and inhibited the bleaching of β-carotene/linoleic acid solution by 59.34%.

Conclusion

The results of showed that of ethanolic extract of Laurus nobilis L leaves the extract is rich in phenolic and flavonoid contents with high antioxidant and antimicrobial activity.

Language:
Persian
Published:
Iranian Journal of Infectious Diseases, Volume:27 Issue: 96, 2022
Pages:
17 to 26
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