The effect of four weeks of exercise and oleuropein supplementation on anxiety and depression behaviors in an animal model of Parkinson's disease

Parkinson's disease is a destroyer of dopamine neurons in the dense structure of the substantia nigra and other areas of the brainstem. Anxiety and depression are common in Parkinson's. The aim of this study was to investigate the effect of oleuropein and exercise on anxiety and depression in animal models of Parkinson's disease. In this experimental study, 40 rats were divided into five groups: control, Parkinson's (6-hydroxy dopamine to the striatum area unilaterally), swimming practice (five sessions per week and 30 minutes each session), oleuropein recipient for 4 weeks (20 mg per kilogram of body weight per day) and combined with swimming practice and oleuropein. To assess anxiety, the elevated plus maze test was performed and to assess depression, the open box test was performed. One-way ANOVA and Tukey's post hoc test were used to determine the differences between the groups. The results showed that the use of oleuropein with exercise significantly increased the duration of Parkinson's model animal in the Plus open maze arms (P<0.05). Also, the use of oleuropein with exercise in open feild box testing significantly increases the number of animals crossing the central square and significantly reduces the number of crossings of marginal squares and the number of hands raised (P<0.05). The results of this study showed that exercise combined with oleuropein consumption can improve anxiety and depression behaviors in Parkinson's rats with its antioxidant effect.