Clinical and Paraclinical Parameters Correlation with Histopathologic Classification in IgA Nephropathy: A Clinicopathologic Study of 57 Cases

In this study histological and clinical data of 57 cases of IgA nephropathy in Hashemi-Nejad hospital diagnosed between 1998 and 2002 were reviewed. There were 43 men(75.4%) and 14 women(24.6%), ranging from 17 to 68 years(mean age 31.8±10.5 years). Each biopsy specimen was subclassified according to WHO classification as follows: class I: no case, class II: 8 cases(14%), class III: 18 cases(31.6%), class IV: 21 cases(36.8%) and class V: 10 cases(17.5%). The analyzed clinical parameters were serum creatinine, proteinuria, hypertension and degree of hematuria(micro or macrohematuria). There was a significant statistical correlation between histopathologic classes and serum creatinine(P<0.001, r=0.6 using Spearman’s test) proteinuria(P=0.037, r=0.276 using Spearman’s test), and hypertension(P=0.036, X2=4.397 using chi-squared test). There was no significant statistical correlation between histopathologic classes and degree of hematuria(P=0.725, X2=0.635 using chi-squared test).