The Effect of Aqueous Extract of Golden Wheat Flower on the Activity of Liver Enzymes (ALT, AST, and ALP) Following Hepatotoxicity Caused by Acetaminophen in Male Rats

This study was aimed at investigating the effect of aqueous extract of golden wheat flower on acetaminophen-induced liver tissue damage in rats. Forty-two male rats were randomly assigned to seven groups of six (control group and five treatment groups) and kept hungry for 12-16 hours the night before the experiment and all groups were given 600 mg/kg daily for five weeks. Acetaminophen was administered orally. During the experiment, based on the weight of mice, 0.2 ml of wheat flower extract with concentrations of 160, 180, 200, 220, 240, and 260 mg/kg orally and one hour after receiving a toxic dose of acetaminophen. Liver enzymes (AST, ALT, and ALP) were assayed and the liver tissue of mice treated was examined under a light microscope. The results of this study showed that the aqueous extract of golden wheat flower affected the activity of aspartate aminotransferase enzyme and at a dose of 260 significantly decreased (p <0.05) compared to other groups. Besides, the severity of liver damage showed a significant difference between the groups; however, the levels of alkaline phosphatase and alanine aminotransferase did not show a significant difference between different groups. The research results proved the effect of the aqueous extract of golden wheat flower in preventing liver tissue damage following liver poisoning caused by taking acetaminophen.