Synthesis of Benzyl Vinyl Ethers Through a Domino Reaction of Benzyl Alcohols with Dimethyl Sulfoxide in the Presence of Arginine and Potassium Hydroxide Without the Use of Metallic Catalysts

Herein, a one-pot, new, and domino method for the synthesis of benzyl vinyl ethers without the use of a metallic catalyst in the presence of arginine and dimethyl-sulfoxide has been reported. Arginine, as an inexpensive and available amino acid, has contributed to the advancement of this reaction. Dimethyl sulfoxide, in addition to the reaction solvent, is effective as a carbon source in the synthesis of benzyl vinyl ethers. Under optimal reaction conditions, a series of benzyl vinyl ether derivatives was synthesized from good to excellent yields and at relatively convenient times. High efficiency (87-87%), easy separation, cheap and affordable materials, cost-effectiveness in terms of time and cost and low-cost reactants are the most important advantages of these reactions.