In many countries, cancer is the second leading cause of fatality after cardiovascular disease. Cancer is a growing problem worldwide and is one of the most important reasons for fatality in human societies. The problems of chemotherapy and radiation therapy and the many side effects that result from their use for the patient, as well as the resistance of cancer cells to common treatments, have led researchers to new drugs with greater effectiveness and less toxicity. One of the best ways to reduce the risk of cancer is to use natural materials. The purpose of this study is the effect of medicinal herbs on cancer in Iran. This study aims to search the types of herbs that are beneficial for the health of body tissues concerning cancer, in order to be able to provide a suitable way to prevent the types of cancer that are more common in humans which has become a major problem in the medical world. In the treatment of cancers from medicinal plants such as Trachyspermum ammi, Crocus sativus, Silybum marianum, Nigella sativa, Cornus mas, Aloe vera, Zingiber officinale, Urtica dioica, Allium cepa, Glycyrrhiza glabra, Peganum harmala, Plantago ovate, Thymus vulgaris, and Elkhorn fern. Some of the most important traditional natural anti-cancer substances include Catharanthus roseus, Podophyllum peltatum, Combreturn cafrum, Campetotheca acuminate, and Brucea antidysenterica. The use of herbal medicines with anti-cancer properties can be used as a substitute or supplement to chemical drugs in treating cancers. Many unique plant species need to be further studied to find anti-cancer compounds.