The prevalence of coronavirus, the restrictions imposed, the closure of educational institutions, the unknown and cognitive ambiguities of this virus, and the resulting mortality rate caused high anxiety in individuals. This study aimed to provide a model for the relationship between mindfulness and corona anxiety mediated by self-compassion and to determine the model's fit based on experimental data. The method of the present study was descriptive-correlational. Three hundred and eighty undergraduate students of Yazd University (193 girls and 187 boys) were selected via available sampling method. The participants answered to the online questionnaires. They included Mindfulness, Self-Compassion, and Corona Anxiety. The data were analyzed using structural equation modeling. The results showed the hypothetical model fitted the experimental data. Mindfulness had a significant direct effect on corona anxiety. Also, the direct effect of self-compassion on corona anxiety was significant. In addition, mindfulness indirectly affected corona anxiety through the mediating variable of self-compassion