Comparison of the Effect of Anesthesia with Isoflurane and TIVA on Liver Enzymes and Coagulation Tests in Patients Undergoing Cholecystectomy

 Anesthetic agents and type of surgery may lead to liver damage after surgery. Inhaled agents are associated with liver dysfunction after surgery. Propofol is expected to have a lower potential for postoperative liver damage. The present study was conducted to compare liver enzyme function after anesthesia with isoflurane and total intravenous anesthesia (TIVA).

 This clinical trial was conducted on 70 patients referred to Imam Ali Hospital in Bojnord. Patients were selected using convenience sampling and then divided into TIVA and Isoflurane groups using block randomization method. During surgery, anesthesia was maintained in the isoflurane group with isoflurane gas (1.2 MAC) and in the TIVA group with infusion of propofol (100 micrograms/kg/minute) and remifentanil (0.1 micrograms/kg/minute). The levels of ALT, AST, ALP, PTT, and INR factors of the patients were examined and compared using laboratory devices before the operation, immediately, 24 and 48 hours after the operation.

 There is no significant difference between the two groups in terms of demographic and interventional variables. ALT enzyme level in TIVA group increased from 17.6±10.7 to 21.2±14.2 and in isoflurane group from 16.7±9.4 to 28.4±16.1 (p<0.05). In other enzymes, this difference was not significant.

 The results of the study showed that the use of both TIVA and Isoflurane methods has an effect on the level of liver enzymes in patients undergoing laparoscopic cholecystectomy surgery.