The newly severe acute respiratory syndrome coronavirus caused by the coronavirus pandemic 2019 (COVID-19) resulted in 150 million infections and 3.5 million deaths worldwide. COVID-19 influenced men more than women, with more severe disease and higher mortality rates. A serious illness affects male reproductive organs, resulting in erectile dysfunction (ED). Although the exact pathophysiology of this disease has not been entirely determined yet, this review highlights the possible mechanisms of COVID-19-related sexual disorders led by COVID-19. In summary, the research shed light on COVID-19 infection can influence men’s sexual performance via endothelial harm in erectile tissue, testicular damage, and mental changes. Still, longitudinal studies should be performed to determine the mechanism of COVID-19 in ED.