This study aimed to investigate the prediction of marital conflicts based on marital quality of life and communication patterns during coronavirus quarantine (Covid-19). The descriptive-correlation method was used. According to the random convenience sampling method, 385 married women in Shiraz were selected by the Cochran formula as the statistical population. The selected population was asked to answer the Marital Conflict Questionnaire (MCQ) (Barati and Sanaee, 1372- solar calendar), Dyadic Adjustment Scale (DAS)(Busby etal, 1995), and Communication Patterns Questionnaire (CPQ)(Christensen and Sullaway, 1984). The data were analyzed by Pearson correlation coefficient and multivariate regression. Findings showed a significant correlation between marital life quality and communication patterns with marital conflicts (P<0/01). Regression analyses also revealed that %27.4 of the variance of marital conflicts was explained by the marital life quality and communication patterns. This study demonstrates that marital life quality and communication patterns significantly contributed to marital conflicts prediction during quarantine (Covid-19).