The effect of resistance training on structural damage of the femur caused by Boldenone injection in male Wistar rats

Article Type:
Research/Original Article (دارای رتبه معتبر)

It is common for athletes to perform resistance exercises along with the use of anabolic steroids, but the effect of medical doses and their abuse along with resistance exercises on the structural destruction of the femur is not known. This study aimed to investigate the effect of resistance training on body weight and femur fractures caused by Boldenone injection in male rats.

Materials and Methods

The 36 male Wistar rats (Weight 189.53±5.94) were randomly divided into 6 groups (in6): 1.Control, 2.Boldenone (2mg/kg), 3.Bodenone (5mg/kg),, (2mg/kg), (5mg/kg). Boldenone steroid was injected twice a week into the rat serine muscle. The resistance training program consisted of eighth weeks of climbing a ladder, and 3 d/w, which began with 50% of body weight of rat and increased to 120% in the eight week. Histopathological changes in quadriceps femur tissue were assessed using H&E. In order to normalize the weight data, Kolmogorov-Smirnov test and to analyze them, one-way ANOVA test was used. For examination of tissue changes was used of Kruskal Wallis.


After group comparison, no significant difference was observed in the weight values ​​of rats. In the groups receiving Boldenone (groups of 2, 3, 5 and 6), mild and moderate damage was observed in the structural tissue of the femur, which was slightly and not statistically significant (P<0.05) improved by performing resistance exercises.


Performing resistance training does not seem to be able to prevent or improve the damage caused by taking Boldenone steroid.

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