Effects of two types of acute resistance exercise with high intensity and volume on α2bβ3 receptor, and platelet function and activation in healthy individuals

The aim of this study was to investigate the effect of two types of resistance exercises of high volume (HV) and high intensity (HI) on α2bβ3 receptor, and markers of platelet activation and function. Among the volunteers, 10 individuals familiar with resistance training (6 women and 4 men; age, 28±5 years; weight, 67.1± 10.7 kg; height, 168±9 cm) performed two resistance exercises of HV and HI including 5 exercises. In HV protocol subjects performed 4 sets of 10-12 repetitions at 70% of 1RM with 1 min rest between sets and exercises and in HI protocol subjects performed 4 sets of 3-5 repetitions at 90% of 1RM with 3 min rest between sets and exercises. Blood samples were taken before, immediately after exercise and after 30 min recovery for measuring PDW, PLT, MPV, PAC1, CD41a, CD42b and CD62p. Data were analyzed using two-way repeated measures of ANOVA. Significant increases in blood lactate levels, PLT following resistance exercise were higher in response to HI protocol were higher than HV protocol. The results showed a significant decrease in CD41a (α2bβ3 receptor) and CD42b, and a significant increase in PAC1 and CD62p (p<0.05). Changes in CD41a, CD62p, and PAC1 were higher following HI than the HV protocol (p<0.05). Based on the findings of present study it could be concluded that α2bβ3 receptor, markers of platelet activation and function change in response to resistance exercise and that intensity of resistance exercise is more effective than volume of exercise.