The response of selected adipokines and insulin resistance to interval resistance training with different intensities in men with obesity
Article Type:
Research/Original Article (دارای رتبه معتبر)

This study aimed to evaluate the effect of 12 weeks of interval resistance training with different intensities (low, medium and high) on bone morphogenetic protein 2 (BMP-2), bone morphogenetic protein 4 (BMP-4) and insulin resistance in obese men.

Materials and Methods

Forty-four obese not trained men, after determining 1RM and based on anthropometric characteristics were divided into the control, low-intensity interval resistance training, medium-intensity interval resistance training, high-intensity interval resistance training groups (in each group, n=11). The protocol of interval resistance training includes 8 movements which were periodic and in different intensities in the form of 3 Set 10 repetitions with 80% 1 RM, rest between sets active, and with 20% intensity and the number of repetitions 15 in the high-intensity group, in the medium intensity group in the form of 3 sets 13 repetitions with 60% RM, resting active sets with 20% intensity and number 15 repetitions and in the low-intensity group in the form of 3 sets of 20 repetitions with 40% 1 RM, rest between sets was active with 20% intensity and the number of repetitions was 15. The first fasting blood sample was obtained 48 hours before and the second blood sample was collected 48 hours after a twelve-week training period. Then the measurements were performed.


The 12 weeks of interval resistance training with different intensities in the training groups led to a significant decrease in BMP-2 and insulin resistance compared to the control group (P < 0.001) but for BMP-4 these decreases were not significant (P = 0.055).


The study showed that different intensities of resistance interval training, especially moderate and high intensity training, can decrease the BMP-2, BMP-4 levels and improve insulin resistance.

Journal of Basic Research in Medical Sciences, Volume:9 Issue: 3, Summer 2022
51 to 60  
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