The Effect of Interval Training and Two Types of Combined Exercises on the Level of Angiopoietin 1 and 2 in Patients During the Rehabilitation Period after Cardiac Surgery (CABG)

Due to the complications caused by surgery, especially involuntary immobility, patients' ability to function is significantly reduced after surgery, so participation in exercise and rehabilitation programs is recommended to patients. The aim of this study was to investigate the effect of interval training and two types of combination on angiopoietin 1, 2 levels in patients in the postoperative rehabilitation period (CABG). A total of 30 cardiac patients operated on in Tehran Heart Center were selected by simple random sampling and randomly divided into three groups (10 patients in each group): interval training, interval training-resistance and continuous-resistance. Exercises were performed for 6 weeks and 3 sessions per week. Interval training were performed from the first to the sixth week with an intensity of 60 to 80% of the maximum heart rate. Continuous exercises were performed from 10 to 20 minutes of activity with an intensity of 60 to 70% of the maximum heart rate. Resistance training included four movements of the upper chest, biceps flexion, thigh extension, and inside the thigh. 2 sets of 10-12 repetitions with an intensity of 50-70% of the maximum repetition were performed from the first to the sixth week. Blood samples were taken 48 and 24 hours before and after the training protocols and the expression of angiopoietin 1, 2 genes was measured by real-time-PCR. The results within the group indicate that there is a significant difference between the pre-test and post-test of angiopoietin 1, 2 in all groups (p ≤ 0.05). Also, comparison of intergroup results in angiopoietin variable 1 and 2 showed that there was no significant difference between training groups in the post-test stage (p ≥ 0.05). All three training methods were able to improve the expression of the studied genes, to make favorable changes in reducing the consequences of heart tissue damage.