An  efficient,  rapid,  and  eco-friendly  protocol  for  one-pot,  four-component  preparation  of dihydropyrano[2,3-c]pyrazole and pyrazolopyranopyrimidine derivatives has been developed using vitamin D as an efficient catalyst. This method involves several advantages such as low-cost and non-toxic catalysts, high yields of products, simple workup, no hazardous solvent, and no need forcolumn chromatography.