Role of DW-MRI in Predicting Pathologic Complete Response after Neoadjuvant Chemoradiation in Patients with Rectal Cancer
Research/Original Article (دارای رتبه معتبر)
BackgroundFollowing neoadjuvant chemoradiation, 25% of patients with rectal cancer experience pathologic complete response (pCR). With the appropriate imaging method for this group of patients, it would be possible to use less invasive methods. The aim of this study was to assess the ability of diffusion-weighted magnetic resonance imaging to predict pCR after neoadjuvant chemoradiation in patients with rectal cancer.
MethodIn this prospective study, 19 patients with rectal cancer were examined. Magnetic resonance imaging of patients with diffusion-weighted imaging was performed in two stages: one week before the start of chemoradiotherapy (CRT) and seven weeks after the end of CRT to evaluate the results of treatment. Apparent diffusion coefficient (ADC) was measured before and after treatment. The percentage of ADC (% ΔADC) increment was also calculated. The patients were divided into three groups according to the surgical report: complete responders, partial responders, and non-responders. Optimal cut-off point was determined via ROC diagram.
ResultsThe mean age of the patients was 52.9 (29-73) years. There were no significant associations between pre and postoperative ADC values and pCR. However, % ΔADC had a significant relationship with complete response to treatment. Based on the ROC chart, the value of 15% was selected as cut-off with 56% specificity and 67% sensitivity. The positive and negative predicting values were 77.8% and 40%, respectively.
ConclusionThe mean %ΔADC increase seems to be a valid tool to differentiate complete responders from non-responders after CRT in locally advanced rectal cancer.
Middle East Journal of Cancer, Volume:14 Issue: 1, Jan 2023
146 to 152
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
با عضویت و پرداخت آنلاین حق اشتراک یکساله به مبلغ 750,000ريال میتوانید 50 عنوان مطلب دانلود کنید!
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.
In order to view content subscription is required
Subscribe magiran.com for 50 € euros via PayPal and download 50 articles during a year.
Please contact us to subscribe your university or library for unlimited access!