The Effect of Eight Weeks of Intense Interval Training on Serum Levels of Adiponectin, Irisin, and Lipid Profile in Women with Non- Alcoholic Fatty Liver Disease

Non- alcoholic fatty liver disease is characterized by fat deposition in liver cells and, if not controlled, may cause fibrosis, cirrhosis, and cell destruction of the liver. Sports activity is one of the contributing factors in the recovery of non-alcoholic fatty liver patients. The aim of this study was to investigate the effect of eight weeks of high- intensity interval training (HIIT) on serum levels of adiponectin, irisin, and lipid profile in women with non- alcoholic fatty liver disease.

In this experimental clinical trial, 25 women with non-alcoholic fatty liver disease with an age range of    30-50 years were selected as a statistical sample based on the inclusion criteria and randomly divided into two exercise groups (13 people) and control groups (12 people). Intense interval training was performed for 8 weeks (four sessions per week and each session lasting 48 to 60 minutes). Blood samples were taken before and after the test to measure the levels of adiponectin, irisin, and lipid profile. Statistical analysis of the data was done using independent t- test and correlated t- test using spss21 software at a significance level of p<0.05.

The results showed that after training intervention, the serum levels of adiponectin (p= 0.049), irisin  (p= 0.004), and HDL (p= 0.005) significantly increased, and LDL (p= 0.001), TG (p= 0.001), TC (p= 0.001) had a significant decrease in the exercise group compared to the control group (p≥0.05).

Considering the positive effects of HIIT on serum levels of irisin, adiponectin, and lipid profile in patients with non- alcoholic fatty liver, it seems that these exercises can be recommended as a non- pharmacological treatment to improve these patients.