Effect of photodynamic therapy as an adjunctive to mechanical debridement on the nonsurgical treatment of peri‑implant mucositis: A randomized controlled clinical trial
Article Type:
Research/Original Article (دارای رتبه معتبر)

The use of photodynamic therapy (PDT) has been evaluated as an adjunctive technique for bacterial decontamination of implants with peri‑implantitis. Given the controversies over the efficacy of the application of PDT to treat peri‑implant diseases, the present clinical study aimed to evaluate the posttherapeutic clinical parameters and cytokine levels in peri‑implant crevicular fluid in patients with peri‑implant mucosal inflammation, receiving mechanical debridement (MD) alone or in association with PDT.

Materials and Methods

In this double‑blinded randomized clinical trial, 52 patients with peri‑implant mucosal inflammation were selected and they were randomly assigned to 2 treatment groups: a MD group and an MD + PDT group using an 805 nm laser and indocyanine green (ICG). Although the decrease in bleeding on probing was the primary outcome, pocket depth, PUS, pain on probing, clinical attachment level, gingival recession, tumor necrosis factor‑α, interleukin (IL)‑1β, IL‑6 and matrix metalloproteinase‑8 were also evaluated at baseline, 2‑week, and 3‑month postintervention. Repeated measure analysis of variance was used to analyze inter‑group differences and a P ≤ 0.05 was considered for significant differences between tested parameters.


Statistically significant improvements (P < 0.001) were detected for all variables after comparison of baseline data with those collected at each time interval of the study. Nevertheless, the inter‑group comparisons of these variables between the baseline, 2‑week, and 3‑month intervals did not reveal any significant decrease in sites treated with either MD alone or MD + PDT.


The application of PDT using 805‑nm laser and ICG as an adjunct therapy to MD did not provide any additional improvements in the clinical or biologic parameters of peri‑implant mucosal inflammation.

Dental Research Journal, Volume:20 Issue: 1, Jan 2023
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