Infectious diseases are always a source of fear and anxiety that following the outbreak of the disease, symptoms of anxiety can be seen in the person, including coronary anxiety, which leads to the continuation of psychological trauma and aggravation of social problems. The aim of this study was to compare coping self-efficacy based on the severity of corona anxiety in citizens of Tehran. The research method was descriptive kind of comparative causal. The statistical population was all citizens of Tehran in April and May of 2020 that 215 people were selected by voluntary sampling with online call through virtual social networks (Telegram and WhatsApp). Data were collected by Coronavirus Anxiety Scale (Alipour et al., 2018) and the Coping Self-Efficacy Scale (Chesni et al., 2005) which were prepared as virtual web-based questionnaires. Also the data obtained from these questionnaires were analyzed by one-way analysis of variance in SPSS-25 software. The results of variance analysis showed that there was a significant difference between mild and severe coronary anxiety group in the mean of coping self-efficacy and problem-oriented coping (p<0/01).Mean self-efficacy and problem-oriented coping did not differ significantly from other coronary anxiety severity confrontations, Also, the mean stop unpleasant emotions and thoughts and get support from friends and family were not differ significantly in all coronary severity confrontations (p<0/05). Therefore, it seems that health officials should pay more attention to the concept of coping self-efficacy as an important indicator in ensuring the mental health of people during the outbreak of coronary anxiety.