Evaluation of Chemerin in Diabetic Type 2 Patients with Metabolic Syndrome in both Gender

Chemerin abnormal level represents a risk indicator of visceral fat increase. It has a role in the incidence of inflammation, insulin resistance, metabolic syndrome, obesity, and diabetes. This study aimed to evaluate Chemerin level in diabetic type 2 patients with metabolic syndrome in both Genders. 

 This study was carried out on the patients referred to the Al-Yarmouk Teaching Hospital in 2021-2022. 88 participants were selected by random sampling method and were divided into two groups including T2DM patients with metabolic syndrome in the experience group (n=55) compared with healthy subjects in the control group (n=38). Triacylglycerol (TG), High-Density Lipoprotein-Cholesterol (HDL-c), Obesity (BMI), serum Chemerin, Hypertension (SBP), age, Fasting Blood Glucose (FBG), and Glycated Haemoglobin (HbA1C) were measured in the two studied groups. Data were analyzed using T-test through SPSS 21 Software.

 A significant difference was observed between the levels of BMI, SBP, FBG, TG, HDL-c, Chemerin weight, DBP, and HbA1c in the studied groups (p=0.05). The rate of WC and HDL-c was higher in the females than in males in the experience group. While, there was a significant increase in the rates of SBP, FBG, TG, and Chemerin in males than females. A positive correlation coefficient was observed between age, SBP, WC, BMI, FBG, TG, and HbA1c with Chemerin level in the experience group.

 An increase in Chemerin level is associated with a high level of triglycerides during the onset of symptoms of metabolic syndrome, age, and gender, which affect the increase of adipokine.