An Overview on the Role of Hemostatic System and the Importance of Clinical Aspects of Blood Coagulation in COVID-19 Disease

COVID-19 disease is considered a respiratory disorder that can affect many body systems, including the hemostasis system, so in this review article, according to the latest findings, we investigate the role of the blood coagulation system in COVID-19 infection.

In this review study, the articles were searched in Medline database using keywords such as “Respiratory infection”, “COVID-19”, “Coagulopathy” .

Ethical Considerations:

 Ethical principles in writing this article have been observed in accordance with the guidelines of the National Ethics Committee and the Committee on Publication Ethics (COPE).

In December 2019, a sudden outbreak of acute respiratory syndrome caused by a new type of coronavirus was reported for the first time in Wuhan, Hubei Province, China. The World Health Organization (WHO) named this virus COVID-19 and the International Committee on Classification of Viruses (ICTV) named it SARS-CoV-2. Many changes in the coagulation profile of COVID-19 patients have been reported, which include changes in the number of platelets as well as changes in coagulation indices such as FDP, D-Dimer, fibrinogen, PT and PTT. With the increase in the number of patients with COVID-19 infection, researchers found out the occurrence of thrombosis and coagulopathy in patients with COVID-19 through numerous investigations.

Due to the increase in the occurrence of coagulation disorders in COVID-19 patients, the administration of anticoagulants is necessary as one of the important arms of the treatment of patients with COVID-19 and can play an effective role in improving the prognosis of patients.