Physical activity reduces the malondialdehyde level in boy children with intellectual disability
Article Type:
Research/Original Article (دارای رتبه معتبر)

  Free radicals in the body create malondialdehyde (MDA), which is one of the most frequent indicators of oxidative stress. Several studies have reported the increase of MDA in inactive persons and individuals with developmental disorders. The purpose of this study, therefore, was to examine whether a program of physical activity reduces MDA in children with intellectual disability.


Twenty boy students with intellectual disability (7 to 9 years old) voluntarily participated in the study. They were randomly divided into experimental and control groups. The experimental group performed a physical curriculum known as sports, play and active recreation for kids (SPARK) for 12 weeks (3 sessions of 45 minutes per week), while the control group was exempted to participate in the program. The level of MDA in blood samples of all participants was measured before and after the intervention. Repeated measures ANOVA was applied to analyze the data (α = 0.05).


Analysis revealed that there was no significant difference between two groups in pretest (P = 0.698, η2 = 0.009).  However, in posttest, the experimental group had significantly lower level of MDA as compared to the control group (P < 0.001, η2 = 0.555).


According to the results, it can be argued that the selected SPARK program reduces MDA which may consequently result in less oxidative stress in children with intellectual disability.

Journal of Pathobiology Reaearch, Volume:25 Issue: 1, Winter 2022
51 to 56  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 990,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
In order to view content subscription is required

Personal subscription
Subscribe for 50 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!