The effect of two month high-intensity interval training and vitamin D supplementation on the blood levels of homocysteine and total antioxidant capacity in overweight women with vitamin D deficiency. A clinical trial study

One of the important goals of therapeutic interventions is to control obesity and vitamin D deficiency, which are associated with the occurrence of cardiovascular disease, metabolic disorders and increased homocysteine. In this study, the effect of high-intensity interval resistance training (HIIRT) and vitamin D on homocysteine and total antioxidant capacity (TAC) ​​levels in overweight women with vitamin D deficiency was investigated.

In this clinical trial study, overweight women with vitamin D deficiency were investigated. The subjects were randomly divided into four groups of 13 (control, exercise, vitamin D and exercise+vitamin D). The exercise groups performed HIIRT with an intensity of 80% of one maximum repetition, and the vitamin D groups consumed vitamin D once a week. The collected data were analyzed using one-way analysis of variance and paired t-tests.

After 8 weeks of research interventions, homocysteine level decreased and TAC significantly increased in the experimental groups (P<0.001). In addition, combined intervention was associated with more changes in homocysteine and TAC levels compared to HIIRT and vitamin D intervention (P<0.001), but HIIRT and vitamin D had a similar effect on the changes of these variables (P>0.05).

It seems that part of the optimal effects of HIIRT and vitamin D consumption in the health development of overweight women with vitamin D deficiency can be induced by increasing TAC and decreasing homocysteine.