The effect of probiotic consumption and intense intermittent exercise on the level of liver enzymes in male rats with steatosis

Fatty liver is one of the increasing diseases in Iran and the world, and for this reason, it is necessary and useful to find a solution to treat or prevent its progress.Therefore, the aim of this study was to investigate the effect of probiotic consumption and intense intermittent exercise on liver enzymes in male rats with steatosis.

In this experimental study, 40 male rats were randomly divided into 5 groups of 8 including healthy control, asetosis, exercise+steatosis, probiotic+steatosis, exercise+probiotic+steatosis. To develop fatty liver, they received high-fat emulsion at the rate of 10 mg/kg daily.consumption of probiotics;The respective groups received 109 CFU/ml of Lactobacillus rhamnosus GG by gavage daily for 5 weeks and 5 days a week. Data were measured by one-way variance method and Bonferroni's post hoc test at the level of p>0.05.

The levels of AST and ALT enzymes in the probiotic group, the exercise group and the probiotic+exercise group were not significantly lower than the healthy control group,but there was a significant decrease compared to the steatosis group (p=0.001).The level of ALP enzyme in the exercise group and the probiotic+exercise group showed a significant decrease compared to the steatosis group, and the steatosis+exercise+probiotic group, although the decrease was not significant compared to the control group, but it had a significant decrease compared to the steatosis group (p= 0.001).

It seems that the combination of probiotic consumption with intense intermittent exercise has a visible effect on the reduction of liver enzymes.