Association between polymorphisms of A251G and 50bp insertion/deletion in SOD1 gene with the risk of acute myeloid leukemia

Acute myeloid leukemia (AML) is a form of cancer characterized by the presence of cells with abnormal differentiation into blood, bone marrow and other body tissues. In AML, blood cells accumulate in the bone marrow, over-producing of oxygen, which can lead to oxidative stress. The aim of this study was to investigate the association of A251G and 50bp del polymorphisms in SOD1 gene with the risk of AML.

Methods and Materials:

 In this case-control study, 200 patients with AML cancer were selected as the patient group and 200 healthy individuals as the control group. The genotypes of A251G single nucleotide polymorphism of SOD1 gene were determined by PCR-RFLP method and Ins / Del 50bp polymorphism of SOD1 gene was determined by conventional PCR method.

The results showed that there was a significant difference between A251G polymorphism AG + GG genotypes (P <0.001) and Ins / Del 50bp polymorphism ID + DD (P = 0. 04) between the control and patient groups.

In conclusion, it was found that both selected polymorphisms are associated with a reduced risk of AML.